The aim of this study was to compare the effects of adjunctive Minocycline HCl Microspheres (Arestin) with debridement alone on the levels of 40 subgingival bacterial species in the treatment of peri-implantitis. Reseachers recruited 208 subjects (from 11 centers in the USA) with at least 1 implant with peri-implantitis and randomized to receive either mechanical debridement alone (n=104) or mechanical debridement followed by Arestin (1 mg) (n=104) at baseline and day 90.

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