For years, researchers believed IgM, a protective type of antibody, played an insignificant role in Sjögren’s syndrome. However, new research, led by University at Buffalo oral biology researcher Jill Kramer, aims to re-examine whether this seemingly harmless antibody is pathogenic or capable of causing disease. The results may lead to a better understanding of IgM’s effect on Sjögren’s syndrome—an incurable autoimmune disorder that affects more than 1 million Americans, 90% of whom are women—and other autoimmune diseases, such as lupus and rheumatoid arthritis.

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