With today’s widespread misuse of prescription drugs for post-operative pain, using drugs before surgery to reduce use of painkillers could be highly desirable. But does it work? The authors of an article published in the current issue of the journal Anesthesia Progress looked at several studies that tackled that question. The combined results suggested that there is no benefit from the preoperative use of ibuprofen and similar drugs in decreasing postoperative pain. Further careful clinical trials are required to provide solid information on this controversial topic.