Substantial evidence has demonstrated that adaptive immune responses are affected by aging, specifically focused on “newly acquired” responses in naïve aged individuals. However, responses to oral bacteria in aging provide a different set of conditions, in which the host has a pre-existing immune response to bacteria that have colonized the individual’s oral cavity over many decades. This investigation examined the characteristics of serum antibody in a cohort of human subjects related to age, oral health, and specific bacterial burden in the oral cavity.

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