In the practice of dentistry, one of the more common dental anomalies we encounter is hypodontia, the condition in which a person is missing one to six teeth. Excluding wisdom teeth, hypodontia reportedly affects between 3% and 8% of the population. The long-term management of hypodontia in the esthetic zone is a particularly challenging situation. Here, Dr. James Schmidt identifies the available options and discusses some of the advantages and disadvantages of each. It is imperative to manage these patients from an interdisciplinary diagnostic and treatment perspective.